I was wondering when someone was going to mention Randy Rhodes. And while Eddie Van Halen is a little more commercial, he's still one of the best; he use to teach his intructor. Other guitarists mimic stuff that wasn't done until Eddie showed up on the scene.
In no specific order...
Van Halen
Rhodes
Hendrix
Page
Beck (the best ever?)
Vaughan
Clapton
Roy Clark
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