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The (7-3) and (6-4) will meet in a matchup of two division rivals. The 49ers are solid favorites, expected to win by at least a touchdown (currently -7). The expected point total for the game is 42.5. Odds & Betting Lines49ers vs Seahawks Betting Information updated as of November 19, 2023, 9:33 PM ET.FavoriteSpreadFavorite Spread OddsUnderdog Spread OddsTotalOver Total OddsUnder Total Odds49ers-7-110-11042.5-110-110ADVERTISEMENT 49ers vs. Seahawks Prediction & PickPick ATS: San Francisco (-7)Pick OU: Over (42.5)Prediction: San Francisco 27 - Seattle 17How to Watch San Francisco vs. SeattleGame Date: Thursday, November 23, 2023Time: 8:20 PM ETVenue: Lumen FieldLocation: Seattle, WashingtonTV: Watch on NBC49ers vs. Seahawks Recent MatchupsOver their last five meetings, San Francisco has tallied four wins versus Seattle.Seattle has been outscored Leonard Fournette Jersey by 48 points in its last five tilts versus San Francisco.San Francisco Betting InfoSan Francisco has played 10 games, posting five wins against the spread.The 49ers have covered the spread twice this season (2-4 ATS) when playing as at least 7-point favorites.San Francisco games this year have gone over the total in four out of 10 opportunities (40%).When playing as moneyline favorites, the 49ers are 7-3 (winning 70% of the time).San Francisco is 4-2 (winning 66.7% of its games) when playing as a moneyline favorite of -310 or shorter.The 49ers have a 75.6% chance to win this contest, based on the implied probability of the moneyline.49ers StatsStatAverage (Total)RankPa s yards254.3 (2,543)8Rush yards132.7 (1,327)6Points scored27.9 (279)5Pa s yards against221.4 (2,214) Jack Youngblood Jersey 15Rush yards against81.4 (814)3Points allowed15.7 (157)1San Francisco's Key PlayersOffenseOn the ground, averages 4.7 yards per attempt (ninth in the NFL) and 82.5 yards per game for 825 total rushing yards (first in the NFL). He has scored nine rushing touchdowns this season.He's also hauled in 43 pa ses (on 52 targets) for 364 receiving yards with five touchdowns. He's averaging 36.4 receving yards and 4.3 catches per game. has 2,662 pa sing yards (sixth in the NFL), 18 touchdowns (fifth in the NFL) and five interceptions this year. He has completed 70.2% of his pa ses, averaging 266.2 yards per game and 9.7 per attempt.He has also rushed for 121 yards (third on the 49ers) and added two touchdowns on the ground, while averaging 12.1 rushing yards per game.In nine games played, is averaging 92.3 yards and 4.8 receptions per Stevie Tu'ikolovatu Jersey game to total 831 receiving yards (10th in the NFL) and 43 catches. He's been targeted 61 times, and has four receiving touchdowns. averages 4.3 receptions and 64.8 yards per game, and has 648 total receiving yards and 43 catches. He's gotten 56 total targets, and has caught five touchdown pa ses.DefenseOn the defensive side, has 90 tackles, 5.0 TFL, 2.5 sacks, and three interceptions in 2023. has 71 tackles, 5.0 TFL, and 1.5 sacks this season. has totaled 28 tackles, 7.0 TFL, and 5.5 sacks this year.So far this season, has 46 tackles, 1.0 TFL, and two interceptions. He's fifth on the 49ers in tackles.Seattle Betting InfoSeattle is 5-4-1 against the spread this year.Seattle's games have finished with a final combined score above the over/under four times this year.The Seahawks have entered the game as underdogs four times this season and won once.Seattle has not entered a game this season J.K. Dobbins Jersey with longer moneyline odds than +250.The oddsmakers' moneyline implies a 28.6% chance of a victory for the Seahawks.Seahawks StatsStatAverage (Total)RankPa s yards230.8 (2,308)13Rush yards96.6 (966)25Points scored21.6 (216)16Pa s yards against233.0 (2,330)21Rush yards against112.6 (1,126)19Points allowed21.8 (218)19Seattle's Key PlayersOffenseThrough 10 games played this year, has ama sed 2,404 pa sing yards, while throwing 12 touchdowns against seven interceptions and completing 65.3% of his attempts. has 613 rushing yards (leading the Seahawks and 10th in the NFL) and six rushing touchdowns, while averaging 61.3 yards per game and 4.1 per attempt (18th in the NFL).Walker has also collected 173 receiving yards (17.3 per game) on 17 catches (1.7 per game). He's been targeted 23 times and has caught one touchdown pa s.D.K. Metcalf has put up 646 receiving yards and three touchdowns on 40 receptions, while being targeted 71 times on the season. has 545 receiving yards and four touchdowns from 51 receptions after getting 74 targets.DefenseBobby Wagner has recorded 2.5 sacks (fifth on the Seahawks) to go with 5.0 TFL and 105 tackles over 10 games in 2023.' stats include 83 tackles, 7.0 TFL, Dominic Proctor Jersey 3.5 sacks, and two pa ses defended.In the 2023 campaign, has 52 tackles, 3.0 TFL, three sacks, and one interception in nine games. stats include 32 tackles, 7.0 TFL, seven sacks, and three pa ses defended in nine games